Epigenetics-neurodevelopmental and neurodegenerative disease

Neurodegenerative disorders are among the major difficulties and among the most medical issues that should be withstanded by the world, particularly in light of expanding population age. They cause the degeneration and death of nerve cells as they form incurable conditions for treatment. According to a collaborative study of the WHO, the World Bank and the Harvard School of Public Health by 2020  neurodegenerative diseases, dementia will be the eighth cause of disease among developed regions.It is also estimated that they will occupy the   world’s second leading cause of death by 2050, overtaking cancer. During embryogenesis and for differentiation of neural cells Epigenetic mechanisms are essential required. Thus, precise understanding of Epigenetic mechanisms, including DNA methylation and histone modification, is important to elucidate the pathogenic pathways in neurodevelopmental disorders

  • Most common neurodegenerative diseases

  • Parkinson's disease

  • Alzheimer disease. 

  • Huntington disease

 

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