Kiyoon Kim has completed her PhD and Postdoctoral studies from School of Medicine, Kyung Hee University. She is a Research Professor of Department of Biochemistry and Molecular Biology.
Despite considerable progress in understanding the function of peroxiredoxin (Prx) in cancer, its expression patterns have not been extensively studied in response to cervical carcinogenesis. We evaluated the expression of Prx isoforms in normal tissue, cervical intraepithelial neoplasia (CIN1, CIN2 and CIN3) and cervical cancer. We found strong pattern of increased Prx II and III immunostaining with increasing severity of the lesion. No difference in staining intensity by grade of lesion was observed for Prx I and IV. Therefore, we conclude that Prx II and III are up-regulated in response to the development of cervical cancer.
Suyun Jeong has completed her Master’s degree from Kyunghee University in Seoul, South Korea. Presently, she is studying about viruses and cancer.
The study was performed to investigate the anti-cancer effect of novel compounds in the liver cancer. We performed with many synthetic compounds which are various forms of anti-cancers. We had screened test anti-cancer drugs and selected compatible two compounds. In the study, the anticancer effect and apoptotic molecular mechanism of two compounds were investigated on the human hepatocellular carcinoma cell, HepG2. The anti-proliferation effects of compounds on the HepG2 cell were analyzed using MTS. We showed the expression levels of anti-apoptotic (Bcl-2) proteins and apoptosisassociated proteins (Bax, caspase-3, PARP) using western blot. The results indicated that two compounds effectively inhibit cell proliferation and promote apoptosis and two compounds down-regulated the level of Bcl-2 protein and up-regulated the activity of Bax, cleaved-Parp, cleaved-Casepase-3 proteins. Therefore, two compounds induce apoptosis of hepG2 through the change of the apoptosis-associated proteins.