Pedro Sanchez Rovira
Jaen Hospital Complex, Spain
Title: A metabolomics approach for therapy response in breast cancer
Biography
Biography: Pedro Sanchez Rovira
Abstract
Due to its broad clinical heterogeneity, the treatment of breast cancer is based on a wide variety of protocols. However, only a fraction of patients will show a benefi cial response. Th e discovery of biomarkers which enable the classifi cation of responders and non-responders patients may have important implications to treatment protocols and outcomes. In this study, we carried out a metabolomic profi ling of 46 serum samples of breast cancer patients at diagnostic to identify potential biomarker candidates that can predict response to neoadjuvant chemotherapy. To this end, we analyzed the samples using liquid chromatography couple to high resolution mass spectrometry LC-HRMS and the data matrix obtained was subjected to univariate and multivariate statistical analysis.