Manal H Al Khanbashi
Higher College of Technology, Oman
Title: Insights of breast cancer epigenetics: An intersection between the endogenous and exogenous systems
Biography
Biography: Manal H Al Khanbashi
Abstract
Epigenetics acts as a vital intersect between environmental factors being exogenous and cellular and pathological processes being endogenous. Many studies have suggested that epigenetics alterations manifest to diseases as result of environmental, microbial, UV light exposure, dietary including alcohol consumption and smoking and lifestyle factors increasing the risk of cancer. Th e reversibility fact of epigenetics eff ects serve as a fertile platform in oncological and cancer studies, of which DNA methylation, histone modifi cation, microRNA expression and many others widen the doors for biomarker search for early detection, diagnosis, classifi cation along with therapy targets and prevention. Aberrations in DNA methylation pattern and miRNA expression profi le are established in breast cancer and exhibit good example of epigenetic eff ect resulting from the exogenous and exogenous interactions. Herein, this paper will shed light on the predisposition of these exogenous epigenetic eff ects factors like diet and the potential reversibility and preventive possibilities of breast cancer as endogenous manifestation.