Biography
Biography: Saeed Soroush
Abstract
Nowadays, According to the high rate of cancer Problems and complications arising from it، Research Is doing in order to find the way to work " for the prevention، The early diagnosis and treat it. Iran, also, like in other countries, is faceing with increase in cancer rate that we can pointing to breast cancer That is the most common cancer with a high rate between women that There is a chance that someone will get this cancer From every 10 to 15 women in Iran. So studies of epigenetic is very important.
Breast cancer has more chance for Progression to tumor in case of being dependent to hormone. Different types of breast cancer are often positive estrogen receptor and positive progesterone receptor And Their growth is stimulated by these hormones And Is restrained by anti-estrogens.
DNA methylation in ESPRI and PGR promoters Has been raised As a mechanism for the spread of ER-negative tumors in cell lines And primary tumors. ER-negative breast cancer cells are Also Missing mRNA Related to estrogen receptor that it can be due to hypomethylation. It has been noted in studies that expresses the ER gene in ER-negative cells by inhibiting methylation It will be activated again that leads to the expansion of the necessary conditions for this type of cancer.