Mehrnaz Ajorloo
Avicenna Research center, Iran
Title: The Effect of DNA Hypomethylation in the Trend of Breast Cancer
Biography
Biography: Mehrnaz Ajorloo
Abstract
Cancer is a disease that ranked first in the world and breast cancer is One of its types that can be caused by environmental and genetic factors. Therefore, more detailed studies on the effects of epigenetic factors in breast cancer Can lead to finding useful outcomes for prevention and treatment. As you know, Controlled Reversible Processes Collection that Causing genetic variations in the expression of genes And marking the gene independent of the change in the nucleotide sequence of the DNA is Epigenetic. The agents of this process alter the expression of the microRNAs in the cell either directly or indirectly and certainly Defect in these mechanisms leads to the activation or Inhibiting different messenger paths and causing cancer.
existing Hypermethylation in epigenetic mechanisms In certain promoters They can activate the expression of inappropriate oncogenes And play a role as a tumor suppressor gene in breast cells In the form of hypermethylated. In recent research, More than 100 hypermethylated genes have been identified in breast tumors with breast cancer cell lines that Most of these methylated genes play an important role in the cell cycle ،Apoptosis ، metastases and they have tissue invasion Angiogenesis and hormonal signalling. The cyclin D2 gene is an important regulator of the cell cycle And increasing its expression Harnesses the Transfer from step G1 to S in the cell cycle. This gene is often methylated in breast cancer and It is posing as the first event in the development of this cancer.