Saeed Soroush
Guilan University of Medical Sciences, Iran
Title: The study of the effect of DNA hypomethylation and miRNA expression in glioblastoma multiforme
Biography
Biography: Saeed Soroush
Abstract
Glioblastoma is the most malignant type of brain tumor and primary brain tumor. This means that the origin of this tumor is in the brain and under the control of the central nervous system. The average survival rate of the disease is about one year. Epigenetic cancer treatment is considered to restore some of the defects due to the reversibility of epigenetic changes. Promoter area methylation in this mechanism leads to reducing expression of the desired gene in glioblastoma. In glioblastoma cancer cells, hypomethylation takes place followed by reduction in DNA expression. Subsequently, tumor suppressor genes such as NEG3 which is a cell growth regulator have an increased expression to repairing. Epigenetic mechanisms including DNA hypomethylation, changes in histones and miRNAs expression can be eff ective through effect on genome function and molecular pathology of glioma. miRNAs could had roles on disturbing genetic stability through effect on DNA methylation and demethylation and also through activating transposons. miRNAs are effective in both normal cells and abnormal cells such as cancer cells. Increasing and decreasing each of these causes the cells to become abnormal. miRNAs have roles in relation to the cancerous process of tumorization, metastasis and angiogenesis that they have a significant usage to detect prognosis as proprietary biomarkers that they can be effective through activating apoptosis in definite treatment.